Question: I am running out of disk space on C:-drive. We see many (millions of) files in C:ProgramDataMicrosoftCryptoRSAMachineKeys

What are these files ?

Why are so many files created? How can we prevent this from happening?Can these files be deleted?

Answer: I have found the answer by some analysis and testing. The problem is caused by SSL checking performed by ESET antivirus software.

Disable SSL scanning in ESET and these files will stop appearing in great quantities.

ESET SSL scanning is also connected to MITM attack warning in Chrome (also see links posted in given Q/A and comments).